Umberto DonatoUSF Morsani College of Medicine, USA
Title: A Case of Medullary Microcarcinoma in the Setting of Cowden’s Syndrome
Cowden’s syndrome (CS) is a rare inherited condition characterized by hamartomas in various organs including the thyroid and mucocutaneous tissues as one of the most distinctive features. We present a rare case of Cowden’s syndrome with medullary microcarcinoma of the thyroid, in a 56 year old male with a history of hamartomatous colon polyps, papillomas of the tongue, skin tags, learning disability in the spectrum of autism and macrocephaly. This was evident on immunohistochemical examination of a nodule in the right thyroid lobe. Calcitonin and carcinoembryonic antigen (CEA) positivity along with C-cell hyperplasia were consistent with a medullary microcarcinoma. Total thyroidectomy was performed. Post-operatively margins were uninvolved by carcinoma. Perineural and lymphatic invasion was not identified. Considering the rarity of this condition and the unique presentation of our patient we believe that reporting this case would add more information to the existing fund of knowledge.
Umberto has undoubtedly demonstrated a passion towards his community. After finishing his high school education at Colegio San Ignacio de Loyola in Puerto Rico he then moved on to complete a Neuroscience degree at Tulane University with a Dean's Honors Scholarship . At Tulane, Umberto graduated in three years as a magna cum laude and served as the president/founder of Tu-Latino, a student led service group at the school that provided English language services for the Latino community in New Orleans. After graduating, Umberto headed on to USFs Morsani College of Medicine where he is currently pursuing his doctorate in medicine. At Morsani, he has demonstrated an unparallel commitment to clinical research immersing himself in a variety of projects at Tampa General Hospital, Moffitt Cancer Center, and The Yale Hearing and Balance Center. Mr. Donato hopes to go into pediatric surgery after completing his MD whilst creating a tangible contribution to the scientific community alongside the nation’s premier clinical researchers.