Background: Rhinoplasty is a complex surgery performed to reshape and improve nasal function using open or closed techniques. In recent years, platelet-rich plasma (PRP) has demonstrated high potential in improving outcomes post rhinoplasty surgery. Methods: From inception to September 2024, PubMed, MEDLINE, Cochrane Library, Google Scholar, and Web of Science were used to conduct a comprehensive literature search for peer-reviewed original research articles. The risk of bias in the included randomized controlled studies was assessed using the risk of bias visualization tool developed by the Cochrane Collaboration. The Newcastle-Ottawa Scale was used to determine the risk of bias in observational studies. Data were then systematically extracted and analyzed. Results: The search yielded 307 records, of which 14 studies meeting the eligibility criteria were included. The analysis showed that PRP improved wound healing, decreased pain, and minimized postoperative complications. Meta-analyses showed significant reductions in nasal crust formation (p = 0.003, SMD = -0.69, 95% CI (-1.14, -0.24)) and statistically insignificant postoperative pain levels (p = 0.31, Standardized Mean Difference (SMD) = -3.90, SMD = 95% CI (-11.36, 3.57)). Moreover, applying PRP improved patient satisfaction and Sino-Nasal Outcome Test (SNOT)-25 scores. It also exhibited enhanced long-term outcomes, including successful septal perforation repair and reduced graft resorption. Conclusion: PRP proved effective in rhinoplasty, significantly improving healing outcomes with minimal complications and satisfaction in patients. Nevertheless, it is essential to consider individual patient factors, surgical objectives, and nasal conditions involved.

Ibrahim Abbas Tawfiq is a medical intern who is enthusiast about ENT and research work. with more than 5 elective rotations in ENT and working on more than 10 ENT related papers, 5 publications already out there.