In recent years, Candida albicans has become a notable opportunistic pathogen, particularly affecting immunocompromised elderly individuals. A major challenge in treating Candida infections is its ability to form biofilms, which exhibit resistance to conventional antifungal treatments, making management more complex. While clove oil has demonstrated potential as an antifungal agent, its specific effects on Candida albicans biofilms remain relatively understudied. Therefore, a thorough review of the existing literature is necessary to evaluate the anti-biofilm properties of clove oil and its mechanisms of action against Candida albicans biofilms. Such an analysis will offer valuable insights into the potential therapeutic applications of clove oil in combating biofilm associated Candida infections. This systematic review aims to assess the effectiveness of clove oil against Candida albicans biofilms. A literature search was conducted using Google Scholar, PubMed, and Science Direct databases. The findings revealed that clove oil exhibited significant anti-biofilm activity against Candida albicans. Our systematic review highlights the potential of clove oil as a therapeutic agent for managing Candida albicans biofilms, offering a promising direction for future research and development.

Dr. Aishwarya Omkar Balsaraf has completed her Bachelors in Dental Surgery from Dr. D.Y.Patil University, Pune, Maharashtra , India and has also completed a Certificate Course in Medical and Forensic Jurisprudence from Savitribai Phule Pune University, Maharashtra, India. She is currently pursuing her Post graduation in Oral and Maxillofacial pathology and Microbiology from Maharashtra University of Health Sciences. She is dealing with Oral oncology and Oral Carcinomas. She has successfully completed her mandatory Clinical Oncology and Histopathology Posting at TATA MEMORIAL HOSPITAL, Navi Mumbai, Maharashtra , India. She has also successfully completed Cell culture and Tissue culture workshop from National Centre for Cell Sciences Pune, Maharashtra , India where she has handled Oral Cancer cell lines. Her area of interest is fabricating, optimizing and characterizing Chitosan and Curcumin nanoparticles and exploring its effect against Candida albicans. She is currently working on herbal agents and its effect on Candida albicans biofilms. She has PUB-MED publications to her name and have also published a Systematic Review on Antibiofilm effect of Clove oil on Candida albicans.